AugmentHealth is a next generation digital-platform for clinical innovation. The underlying design of AugmentHealth is based on an AI powered methodological knowledge-machine that orchestrates a suite of advanced technologies, clinical wisdom, and scientific approach to create a highly intelligent, and secured data infrastructure to overcome the challenges arising in the multifarious application of clinical discovery. This advanced infrastructure includes: 1) the knowledge creation framework that supports quality meta-design to harness untapped knowledge scientifically; 2) the evaluating framework that effects capturing, evaluating and analyzing scientifically-based data at right points of patient journey to answer clinical hypothesis and optimize the best suited model of healthcare; and 3) the adaptation framework bridges research with practice, broader-collaboration with local relevance, and evolves the application seamlessly and rapidly when the unexpected or unpredictable changes arise to ensure long-term sustainable success.